Transcription factors with Perturb-seq knockdown data for MORN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MORN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MORN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:2,132,340–2,134,100 | 258.1 kb | Distal (>10kb) Multiome | 508 | |
| chr1:2,189,382–2,190,314 | 201.9 kb | Distal (>10kb) Multiome HiCAR | 719 | |
| chr1:2,194,502–2,195,788 | 196.5 kb | Distal (>10kb) Multiome HiCAR | 789 | |
| chr1:2,199,148–2,199,756 | 192.1 kb | Distal (>10kb) Multiome HiCAR | 445 | |
| chr1:2,204,191–2,206,396 | 186.4 kb | Distal (>10kb) Multiome HiCAR | 597 | |
| chr1:2,212,255–2,213,305 | 178.8 kb | Distal (>10kb) Multiome | 601 | |
| chr1:2,226,557–2,228,163 | 163.7 kb | Distal (>10kb) Multiome | 675 | |
| chr1:2,248,086–2,248,655 | 143.1 kb | Distal (>10kb) Multiome | 296 | |
| chr1:2,279,142–2,279,636 | 112.1 kb | Distal (>10kb) Multiome | 172 | |
| chr1:2,311,328–2,311,918 | 79.9 kb | Distal (>10kb) Multiome | 366 | |
| chr1:2,314,340–2,315,728 | 76.5 kb | Distal (>10kb) Multiome | 557 | |
| chr1:2,381,779–2,382,023 | 9.5 kb | Proximal (<10kb) | 375 | |
| chr1:2,391,076–2,392,400 | 146 bp | At TSS Multiome | 820 | |
| chr1:2,411,953–2,414,836 | 21.1 kb | Distal (>10kb) Multiome | 918 | |
| chr1:2,525,908–2,527,142 | 134.9 kb | Distal (>10kb) Multiome | 668 | |
| chr1:2,529,108–2,529,820 | 137.8 kb | Distal (>10kb) Multiome | 222 | |
| chr1:2,545,676–2,548,580 | 156.8 kb | Distal (>10kb) Multiome | 918 | |
| chr1:2,585,182–2,587,696 | 195.1 kb | Distal (>10kb) Multiome | 748 | |
| chr1:2,642,358–2,643,801 | 251.7 kb | Distal (>10kb) Multiome | 706 | |
| chr1:3,453,034–3,455,700 | 1061.7 kb | Distal (>10kb) Multiome HiCAR | 874 |
Genomic view of the MORN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.