Predicted to enable chromatin binding activity. Involved in double-strand break repair via homologous recombination; positive regulation of double-strand break repair via homologous recombination; and regulation of cell cycle. Located in nuclear speck. Part of NuA4 histone acetyltransferase complex; Sin3-type complex; and nucleosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MORF4L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MORF4L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MORF4L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:78,619,950–78,621,461 | 252.8 kb | Distal (>10kb) Multiome | 274 | |
| chr15:78,640,579–78,641,869 | 231.7 kb | Distal (>10kb) Multiome | 406 | |
| chr15:78,671,569–78,672,301 | 201.1 kb | Distal (>10kb) Multiome | 254 | |
| chr15:78,810,245–78,812,147 | 61.4 kb | Distal (>10kb) Multiome | 505 | |
| chr15:78,872,212–78,873,881 | 780 bp | At TSS Multiome | 950 | |
| chr15:78,944,219–78,945,521 | 72.2 kb | Distal (>10kb) Multiome | 734 | |
| chr15:79,089,365–79,090,935 | 217.7 kb | Distal (>10kb) Multiome | 289 |
Genomic view of the MORF4L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.