In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for MORC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MORC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MORC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:106,726,146–106,727,669 | 273.3 kb | Distal (>10kb) Multiome | 481 | |
| chrX:106,802,208–106,803,452 | 197.4 kb | Distal (>10kb) Multiome | 521 | |
| chrX:106,932,851–106,934,117 | 66.4 kb | Distal (>10kb) Multiome | 315 | |
| chrX:106,999,035–106,999,384 | 693 bp | At TSS | 198 | |
| chrX:106,999,512–107,000,567 | 169 bp | At TSS Multiome | 501 | |
| chrX:107,205,778–107,206,873 | 206.4 kb | Distal (>10kb) Multiome | 440 | |
| chrX:107,355,186–107,356,118 | 355.6 kb | Distal (>10kb) Multiome HiCAR | 63 |
Genomic view of the MORC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.