This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.[provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for MOB4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MOB4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MOB4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:197,309,737–197,311,360 | 205.3 kb | Distal (>10kb) Multiome | 642 | |
| chr2:197,322,642–197,323,971 | 192.7 kb | Distal (>10kb) Multiome | 185 | |
| chr2:197,434,572–197,435,653 | 81.0 kb | Distal (>10kb) Multiome | 937 | |
| chr2:197,452,830–197,454,321 | 62.7 kb | Distal (>10kb) Multiome | 1033 | |
| chr2:197,498,722–197,500,854 | 16.0 kb | Distal (>10kb) Multiome | 1173 | |
| chr2:197,512,587–197,512,779 | 3.3 kb | Proximal (<10kb) | 3 | |
| chr2:197,515,482–197,516,752 | 52 bp | At TSS Multiome | 1138 | |
| chr2:197,521,562–197,522,018 | 5.5 kb | Proximal (<10kb) | 10 | |
| chr2:197,586,916–197,587,749 | 71.4 kb | Distal (>10kb) Multiome | 118 | |
| chr2:197,704,733–197,706,212 | 189.3 kb | Distal (>10kb) Multiome | 870 | |
| chr2:197,785,007–197,786,878 | 270.2 kb | Distal (>10kb) Multiome | 322 | |
| chr2:197,804,172–197,805,545 | 288.5 kb | Distal (>10kb) Multiome | 556 |
Genomic view of the MOB4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.