This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for MNS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MNS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MNS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:56,242,930–56,244,999 | 221.5 kb | Distal (>10kb) Multiome | 643 | |
| chr15:56,245,857–56,246,386 | 218.8 kb | Distal (>10kb) Multiome | 738 | |
| chr15:56,364,869–56,365,893 | 99.7 kb | Distal (>10kb) Multiome | 591 | |
| chr15:56,464,770–56,465,573 | 94 bp | At TSS Multiome | 565 | |
| chr15:56,732,731–56,733,957 | 268.4 kb | Distal (>10kb) Multiome | 919 |
Genomic view of the MNS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.