Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:26,672,265–26,673,339 | 1128.9 kb | Distal (>10kb) Multiome HiCAR | 604 | |
| chr22:27,670,625–27,671,125 | 130.9 kb | Distal (>10kb) Multiome | 433 | |
| chr22:27,800,250–27,802,619 | 158 bp | At TSS Multiome | 403 | |
| chr22:27,804,765–27,805,000 | 3.0 kb | Proximal (<10kb) | 234 | |
| chr22:27,810,161–27,810,949 | 8.4 kb | Proximal (<10kb) | 165 | |
| chr22:27,918,553–27,920,341 | 117.6 kb | Distal (>10kb) Multiome | 804 |
Genomic view of the MN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.