Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MMP14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MMP14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MMP14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:22,556,665–22,557,670 | 279.3 kb | Distal (>10kb) Multiome HiCAR | 771 | |
| chr14:22,560,678–22,561,385 | 275.5 kb | Distal (>10kb) Multiome HiCAR | 502 | |
| chr14:22,570,258–22,571,116 | 266.0 kb | Distal (>10kb) Multiome | 460 | |
| chr14:22,588,929–22,590,086 | 247.1 kb | Distal (>10kb) Multiome | 964 | |
| chr14:22,597,878–22,599,136 | 238.2 kb | Distal (>10kb) Multiome | 834 | |
| chr14:22,766,419–22,767,375 | 69.9 kb | Distal (>10kb) Multiome | 988 | |
| chr14:22,821,826–22,823,530 | 13.7 kb | Distal (>10kb) Multiome | 649 | |
| chr14:22,829,704–22,830,328 | 6.6 kb | Proximal (<10kb) Multiome | 871 | |
| chr14:22,836,107–22,837,017 | 101 bp | At TSS Multiome | 320 | |
| chr14:22,837,269–22,838,446 | 710 bp | At TSS | 512 | |
| chr14:22,852,845–22,853,709 | 16.7 kb | Distal (>10kb) Multiome | 788 | |
| chr14:22,870,967–22,873,202 | 35.0 kb | Distal (>10kb) Multiome | 1167 | |
| chr14:22,882,594–22,883,886 | 46.6 kb | Distal (>10kb) Multiome | 289 | |
| chr14:22,886,371–22,887,824 | 50.6 kb | Distal (>10kb) Multiome | 639 | |
| chr14:22,918,527–22,919,975 | 82.8 kb | Distal (>10kb) Multiome | 641 | |
| chr14:22,928,961–22,930,849 | 93.0 kb | Distal (>10kb) Multiome | 1108 | |
| chr14:22,956,530–22,957,512 | 120.5 kb | Distal (>10kb) Multiome | 983 | |
| chr14:22,981,215–22,983,249 | 146.1 kb | Distal (>10kb) Multiome | 935 | |
| chr14:23,006,674–23,007,583 | 170.6 kb | Distal (>10kb) Multiome | 1097 | |
| chr14:23,020,642–23,021,291 | 184.4 kb | Distal (>10kb) Multiome | 148 | |
| chr14:23,101,326–23,101,861 | 265.1 kb | Distal (>10kb) Multiome | 83 |
Genomic view of the MMP14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.