This protein is expressed by in vitro differentiated macrophages but not freshly isolated monocytes. Although sequence analysis identifies seven potential transmembrane domains, this protein has little homology to G-protein receptors and it has not been positively identified as a receptor. A suggested alternative function is that of an ion channel protein in maturing macrophages. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MMD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MMD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MMD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:55,238,003–55,239,335 | 183.4 kb | Distal (>10kb) Multiome | 880 | |
| chr17:55,264,122–55,265,272 | 157.0 kb | Distal (>10kb) Multiome | 646 | |
| chr17:55,420,704–55,422,494 | 87 bp | At TSS Multiome | 852 | |
| chr17:55,607,745–55,608,875 | 186.2 kb | Distal (>10kb) Multiome | 256 | |
| chr17:55,641,408–55,642,127 | 219.9 kb | Distal (>10kb) Multiome | 181 |
Genomic view of the MMD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.