The gene variously symbolized ALL1, HRX, or MLL located on 11q23 has been demonstrated to be fused with a number of translocation partners in cases of leukemia. t(1;11)(q21;q23) translocations that fused the MLL gene to a gene on chromosomal band 1q21 in 2 infants with acute myelomonocytic leukemia have been demonstrated. The N-terminal portion of the MLL gene is critical for leukemogenesis in translocations involving band 11q23. This gene encodes 90 amino acids. It was found to be highly expressed in the thymus but not in peripheral lymphoid tissues. In contrast to its restricted distribution in normal hematopoietic tissue, this gene was expressed in all leukemic cell lines tested. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MLLT11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MLLT11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MLLT11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:150,875,863–150,877,222 | 183.7 kb | Distal (>10kb) Multiome | 912 | |
| chr1:150,925,543–150,926,754 | 134.1 kb | Distal (>10kb) Multiome | 813 | |
| chr1:150,973,876–150,975,458 | 85.5 kb | Distal (>10kb) Multiome | 590 | |
| chr1:150,979,331–150,979,990 | 80.8 kb | Distal (>10kb) Multiome | 562 | |
| chr1:150,981,212–150,981,672 | 79.0 kb | Distal (>10kb) Multiome | 379 | |
| chr1:151,006,389–151,007,024 | 53.6 kb | Distal (>10kb) Multiome | 496 | |
| chr1:151,008,116–151,008,852 | 52.0 kb | Distal (>10kb) Multiome | 763 | |
| chr1:151,047,405–151,048,764 | 11.8 kb | Distal (>10kb) Multiome | 714 | |
| chr1:151,059,187–151,059,842 | 760 bp | At TSS Multiome | 821 | |
| chr1:151,060,204–151,060,723 | 115 bp | At TSS Multiome | 346 | |
| chr1:151,070,369–151,071,463 | 10.7 kb | Distal (>10kb) Multiome | 835 | |
| chr1:151,131,105–151,132,256 | 71.0 kb | Distal (>10kb) Multiome | 247 | |
| chr1:151,145,115–151,147,333 | 86.4 kb | Distal (>10kb) Multiome | 709 | |
| chr1:151,165,133–151,166,350 | 105.5 kb | Distal (>10kb) Multiome | 940 | |
| chr1:151,189,687–151,190,378 | 129.8 kb | Distal (>10kb) Multiome | 875 | |
| chr1:151,198,185–151,199,073 | 138.1 kb | Distal (>10kb) Multiome | 721 | |
| chr1:151,254,421–151,255,083 | 194.4 kb | Distal (>10kb) Multiome | 770 | |
| chr1:151,281,008–151,283,557 | 221.0 kb | Distal (>10kb) Multiome | 1121 | |
| chr1:151,327,019–151,328,343 | 267.2 kb | Distal (>10kb) Multiome | 719 | |
| chr1:151,346,796–151,347,793 | 286.9 kb | Distal (>10kb) Multiome | 711 |
Genomic view of the MLLT11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.