This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for MLF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MLF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MLF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:158,329,456–158,330,387 | 241.3 kb | Distal (>10kb) Multiome | 113 | |
| chr3:158,339,424–158,340,336 | 231.2 kb | Distal (>10kb) Multiome | 254 | |
| chr3:158,570,578–158,571,791 | 26 bp | At TSS Multiome | 632 | |
| chr3:158,643,965–158,644,957 | 73.3 kb | Distal (>10kb) Multiome | 928 | |
| chr3:158,671,766–158,673,071 | 101.5 kb | Distal (>10kb) Multiome | 479 | |
| chr3:158,731,475–158,733,286 | 161.2 kb | Distal (>10kb) Multiome | 470 | |
| chr3:158,801,057–158,802,803 | 230.8 kb | Distal (>10kb) Multiome | 932 |
Genomic view of the MLF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.