This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for MKNK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MKNK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MKNK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:46,340,061–46,341,413 | 276.1 kb | Distal (>10kb) Multiome | 967 | |
| chr1:46,394,021–46,394,849 | 222.4 kb | Distal (>10kb) Multiome | 795 | |
| chr1:46,401,942–46,402,392 | 214.6 kb | Distal (>10kb) Multiome | 511 | |
| chr1:46,406,082–46,407,120 | 210.3 kb | Distal (>10kb) Multiome | 299 | |
| chr1:46,442,171–46,443,351 | 174.1 kb | Distal (>10kb) Multiome | 649 | |
| chr1:46,448,113–46,448,679 | 168.4 kb | Distal (>10kb) Multiome HiCAR | 143 | |
| chr1:46,466,221–46,467,348 | 150.1 kb | Distal (>10kb) Multiome | 398 | |
| chr1:46,489,045–46,490,312 | 127.1 kb | Distal (>10kb) Multiome | 381 | |
| chr1:46,516,974–46,517,563 | 99.6 kb | Distal (>10kb) Multiome | 328 | |
| chr1:46,525,135–46,525,776 | 91.4 kb | Distal (>10kb) Multiome | 169 | |
| chr1:46,526,636–46,527,311 | 89.8 kb | Distal (>10kb) Multiome | 225 | |
| chr1:46,532,918–46,533,689 | 83.7 kb | Distal (>10kb) Multiome HiCAR | 254 | |
| chr1:46,603,644–46,604,906 | 12.6 kb | Distal (>10kb) Multiome | 784 | |
| chr1:46,613,913–46,614,131 | 9.6 kb | Proximal (<10kb) | 204 | |
| chr1:46,616,228–46,617,226 | 112 bp | At TSS Multiome | 517 | |
| chr1:46,624,007–46,624,411 | 7.2 kb | Proximal (<10kb) | 40 | |
| chr1:46,667,821–46,668,764 | 51.5 kb | Distal (>10kb) Multiome | 668 | |
| chr1:46,689,209–46,690,044 | 72.7 kb | Distal (>10kb) Multiome | 143 | |
| chr1:46,718,615–46,719,657 | 102.4 kb | Distal (>10kb) Multiome | 860 | |
| chr1:46,788,642–46,789,579 | 172.2 kb | Distal (>10kb) Multiome | 28 | |
| chr1:47,179,069–47,179,667 | 562.5 kb | Distal (>10kb) Multiome HiCAR | 660 |
Genomic view of the MKNK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.