Transcription factors with Perturb-seq knockdown data for MIR4300HG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIR4300HG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIR4300HG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:82,695,267–82,696,305 | 22.4 kb | Distal (>10kb) Multiome | 385 | |
| chr11:82,708,632–82,709,149 | 9.1 kb | Proximal (<10kb) | 16 | |
| chr11:82,714,456–82,715,368 | 2.9 kb | Proximal (<10kb) | 96 | |
| chr11:82,718,095–82,718,738 | at TSS | At TSS | 135 | |
| chr11:82,732,363–82,734,437 | 15.6 kb | Distal (>10kb) Multiome | 442 | |
| chr11:82,750,605–82,751,145 | 32.6 kb | Distal (>10kb) Multiome | 218 | |
| chr11:82,775,808–82,776,868 | 57.8 kb | Distal (>10kb) Multiome | 252 | |
| chr11:82,899,722–82,902,187 | 183.4 kb | Distal (>10kb) Multiome HiCAR | 1001 | |
| chr11:82,970,431–82,971,628 | 252.5 kb | Distal (>10kb) Multiome | 188 | |
| chr11:84,234,389–84,235,507 | 1516.7 kb | Distal (>10kb) Multiome HiCAR | 141 |
Genomic view of the MIR4300HG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.