Transcription factors with Perturb-seq knockdown data for MIR2052HG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIR2052HG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIR2052HG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:74,320,238–74,322,101 | 279.2 kb | Distal (>10kb) Multiome | 590 | |
| chr8:74,349,958–74,351,029 | 249.3 kb | Distal (>10kb) Multiome | 920 | |
| chr8:74,599,495–74,599,750 | 24 bp | At TSS | 3 | |
| chr8:74,601,976–74,602,468 | 2.2 kb | Proximal (<10kb) | 138 | |
| chr8:74,605,838–74,606,352 | 6.3 kb | Proximal (<10kb) Multiome | 104 |
Genomic view of the MIR2052HG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.