Transcription factors with Perturb-seq knockdown data for MIR1915HG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIR1915HG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIR1915HG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:21,281,583–21,282,796 | 214.8 kb | Distal (>10kb) Multiome HiCAR | 230 | |
| chr10:21,313,840–21,314,525 | 182.8 kb | Distal (>10kb) Multiome HiCAR | 145 | |
| chr10:21,417,277–21,417,788 | 79.6 kb | Distal (>10kb) Multiome | 150 | |
| chr10:21,489,146–21,489,456 | 7.6 kb | Proximal (<10kb) | 20 | |
| chr10:21,494,178–21,494,459 | 2.6 kb | Proximal (<10kb) | 154 | |
| chr10:21,494,570–21,495,134 | 1.9 kb | Proximal (<10kb) | 495 | |
| chr10:21,495,254–21,497,513 | 1.1 kb | Proximal (<10kb) Multiome | 1097 | |
| chr10:21,499,682–21,500,896 | 2.6 kb | Proximal (<10kb) | 201 | |
| chr10:21,506,850–21,507,457 | 9.8 kb | Proximal (<10kb) | 60 | |
| chr10:21,508,081–21,511,137 | 13.5 kb | Distal (>10kb) Multiome | 373 | |
| chr10:21,515,560–21,517,745 | 19.1 kb | Distal (>10kb) Multiome | 690 | |
| chr10:21,524,213–21,526,810 | 29.0 kb | Distal (>10kb) Multiome | 1100 | |
| chr10:21,527,043–21,527,629 | 30.4 kb | Distal (>10kb) Multiome | 673 | |
| chr10:21,533,309–21,535,662 | 37.1 kb | Distal (>10kb) Multiome | 1089 | |
| chr10:21,607,324–21,607,893 | 110.5 kb | Distal (>10kb) Multiome | 105 | |
| chr10:21,727,364–21,728,215 | 230.7 kb | Distal (>10kb) Multiome | 323 | |
| chr10:21,751,037–21,752,796 | 254.5 kb | Distal (>10kb) Multiome | 246 |
Genomic view of the MIR1915HG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.