Transcription factors with Perturb-seq knockdown data for MIR130AHG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIR130AHG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIR130AHG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:57,345,508–57,346,149 | 303.4 kb | Distal (>10kb) Multiome | 241 | |
| chr11:57,349,624–57,350,269 | 299.3 kb | Distal (>10kb) Multiome | 357 | |
| chr11:57,426,113–57,427,448 | 222.1 kb | Distal (>10kb) Multiome | 451 | |
| chr11:57,457,029–57,457,825 | 191.8 kb | Distal (>10kb) Multiome | 458 | |
| chr11:57,460,127–57,461,576 | 188.6 kb | Distal (>10kb) Multiome | 418 | |
| chr11:57,480,236–57,481,014 | 168.7 kb | Distal (>10kb) Multiome | 300 | |
| chr11:57,482,336–57,483,518 | 166.1 kb | Distal (>10kb) Multiome | 338 | |
| chr11:57,493,430–57,494,126 | 155.5 kb | Distal (>10kb) Multiome | 521 | |
| chr11:57,499,261–57,500,331 | 149.4 kb | Distal (>10kb) Multiome | 548 | |
| chr11:57,514,003–57,516,118 | 134.8 kb | Distal (>10kb) Multiome | 833 | |
| chr11:57,530,326–57,531,572 | 118.3 kb | Distal (>10kb) Multiome | 824 | |
| chr11:57,567,377–57,568,664 | 81.1 kb | Distal (>10kb) Multiome HiCAR | 665 | |
| chr11:57,597,419–57,598,821 | 51.1 kb | Distal (>10kb) Multiome | 359 | |
| chr11:57,637,508–57,640,656 | 11.0 kb | Distal (>10kb) Multiome | 699 | |
| chr11:57,641,091–57,641,256 | 2.7 kb | Proximal (<10kb) | 70 | |
| chr11:57,641,577–57,641,788 | 3.2 kb | Proximal (<10kb) | 83 | |
| chr11:57,644,541–57,645,304 | 4.3 kb | Proximal (<10kb) Multiome | 237 | |
| chr11:57,645,540–57,646,495 | 7.2 kb | Proximal (<10kb) | 111 | |
| chr11:57,646,682–57,652,802 | 674 bp | At TSS Multiome | 580 | |
| chr11:57,653,349–57,654,303 | 4.1 kb | Proximal (<10kb) | 37 | |
| chr11:57,656,843–57,658,231 | 8.4 kb | Proximal (<10kb) Multiome | 827 | |
| chr11:57,666,634–57,668,805 | 18.6 kb | Distal (>10kb) Multiome | 958 | |
| chr11:57,711,417–57,713,054 | 63.0 kb | Distal (>10kb) Multiome | 857 | |
| chr11:57,740,872–57,742,140 | 92.2 kb | Distal (>10kb) Multiome | 973 | |
| chr11:57,761,276–57,762,144 | 112.5 kb | Distal (>10kb) Multiome | 612 | |
| chr11:57,778,066–57,779,000 | 129.5 kb | Distal (>10kb) Multiome | 688 | |
| chr11:57,780,962–57,781,951 | 132.4 kb | Distal (>10kb) Multiome | 317 | |
| chr11:57,800,273–57,801,159 | 151.5 kb | Distal (>10kb) Multiome | 547 | |
| chr11:57,902,618–57,904,039 | 254.1 kb | Distal (>10kb) Multiome | 362 |
Genomic view of the MIR130AHG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.