Transcription factors with Perturb-seq knockdown data for MIR124-2HG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIR124-2HG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIR124-2HG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:63,167,915–63,169,292 | 1204.6 kb | Distal (>10kb) Multiome HiCAR | 983 | |
| chr8:64,368,348–64,371,603 | 2.6 kb | Proximal (<10kb) Multiome | 451 | |
| chr8:64,371,933–64,374,572 | 30 bp | At TSS Multiome | 219 | |
| chr8:64,376,513–64,378,568 | 5.0 kb | Proximal (<10kb) Multiome | 340 | |
| chr8:64,379,719–64,380,373 | 6.6 kb | Proximal (<10kb) | 249 | |
| chr8:64,380,474–64,380,806 | 7.3 kb | Proximal (<10kb) | 67 | |
| chr8:64,382,021–64,382,391 | 8.9 kb | Proximal (<10kb) | 187 | |
| chr8:64,579,671–64,582,347 | 207.8 kb | Distal (>10kb) Multiome | 477 |
Genomic view of the MIR124-2HG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.