Predicted to act upstream of or within several processes, including long-term synaptic potentiation; miRNA-mediated post-transcriptional gene silencing; and sensory perception of sound. Predicted to be part of RISC complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for MIR124-1HG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIR124-1HG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIR124-1HG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:9,898,231–9,899,122 | 4.8 kb | Proximal (<10kb) Multiome | 137 | |
| chr8:9,902,165–9,902,430 | 967 bp | At TSS | 38 | |
| chr8:9,903,857–9,904,888 | 912 bp | At TSS Multiome | 164 | |
| chr8:9,906,366–9,907,146 | 3.5 kb | Proximal (<10kb) Multiome | 253 | |
| chr8:10,054,019–10,055,820 | 151.3 kb | Distal (>10kb) Multiome | 761 |
Genomic view of the MIR124-1HG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.