This gene encodes a protein that interacts with the oncogene protein insulin-like growth factor binding protein 2 and may function as an inhibitor of cell migration and invasion. This protein also interacts with the cell division protein 20 and may be involved in regulating mitotic progression. This protein may function as a tumor suppressor by inhibiting the growth or certain cancers. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for MIIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:11,735,752–11,736,686 | 283.3 kb | Distal (>10kb) Multiome | 714 | |
| chr1:11,784,926–11,785,439 | 234.2 kb | Distal (>10kb) Multiome | 531 | |
| chr1:11,802,827–11,804,002 | 215.9 kb | Distal (>10kb) Multiome | 507 | |
| chr1:11,805,133–11,806,702 | 213.4 kb | Distal (>10kb) Multiome | 1034 | |
| chr1:11,876,145–11,876,721 | 143.0 kb | Distal (>10kb) Multiome | 56 | |
| chr1:11,907,175–11,910,389 | 111.0 kb | Distal (>10kb) Multiome | 1299 | |
| chr1:11,925,969–11,926,788 | 93.0 kb | Distal (>10kb) Multiome | 632 | |
| chr1:11,934,261–11,935,008 | 84.8 kb | Distal (>10kb) Multiome | 809 | |
| chr1:11,979,601–11,980,894 | 39.2 kb | Distal (>10kb) Multiome | 932 | |
| chr1:12,019,010–12,020,110 | 62 bp | At TSS Multiome | 841 | |
| chr1:12,049,082–12,050,305 | 30.5 kb | Distal (>10kb) Multiome | 142 | |
| chr1:12,067,600–12,068,080 | 48.4 kb | Distal (>10kb) Multiome | 128 | |
| chr1:12,078,792–12,079,863 | 60.2 kb | Distal (>10kb) Multiome | 281 | |
| chr1:12,166,812–12,167,546 | 147.5 kb | Distal (>10kb) Multiome | 414 | |
| chr1:12,208,729–12,209,345 | 189.6 kb | Distal (>10kb) Multiome | 331 | |
| chr1:12,229,625–12,230,345 | 210.5 kb | Distal (>10kb) Multiome | 666 |
Genomic view of the MIIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.