Enables protein heterodimerization activity and protein homodimerization activity. Involved in mitochondrial fusion. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MIGA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIGA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIGA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:128,771,658–128,772,301 | 264.6 kb | Distal (>10kb) Multiome | 940 | |
| chr9:128,786,928–128,787,516 | 249.4 kb | Distal (>10kb) Multiome | 1040 | |
| chr9:128,818,208–128,819,406 | 218.2 kb | Distal (>10kb) Multiome | 839 | |
| chr9:128,829,505–128,830,189 | 206.8 kb | Distal (>10kb) Multiome | 782 | |
| chr9:128,881,863–128,882,454 | 154.6 kb | Distal (>10kb) Multiome | 777 | |
| chr9:128,921,941–128,922,727 | 114.4 kb | Distal (>10kb) Multiome | 378 | |
| chr9:128,947,329–128,947,815 | 89.0 kb | Distal (>10kb) Multiome | 865 | |
| chr9:129,027,821–129,028,677 | 8.2 kb | Proximal (<10kb) Multiome | 639 | |
| chr9:129,036,276–129,036,937 | 150 bp | At TSS Multiome | 736 | |
| chr9:129,080,488–129,081,502 | 44.4 kb | Distal (>10kb) Multiome | 755 | |
| chr9:129,110,314–129,111,708 | 74.4 kb | Distal (>10kb) Multiome | 881 | |
| chr9:129,177,207–129,178,809 | 141.7 kb | Distal (>10kb) Multiome | 824 | |
| chr9:129,208,459–129,208,914 | 172.0 kb | Distal (>10kb) Multiome | 108 | |
| chr9:129,334,082–129,334,794 | 297.7 kb | Distal (>10kb) Multiome | 928 |
Genomic view of the MIGA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.