MIF4GD
MIF4G domain containing | AD023, MGC45027, SLIP1, MIFD

This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

Member of: DE-1
Biological processes 15 terms
Expression (TPM)
MIF4GD — as a Regulated Gene

TFs regulating MIF4GD 0 TFs

Transcription factors with Perturb-seq knockdown data for MIF4GD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIF4GD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to MIF4GD

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIF4GD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:74,972,019–74,973,116 298.4 kb Distal (>10kb) Multiome 607
chr17:74,982,006–74,982,936 288.8 kb Distal (>10kb) Multiome 952
chr17:74,987,081–74,988,770 283.6 kb Distal (>10kb) Multiome 702
chr17:75,012,158–75,013,285 258.4 kb Distal (>10kb) Multiome 1058
chr17:75,033,550–75,035,757 236.1 kb Distal (>10kb) Multiome 1228
chr17:75,046,451–75,047,855 224.1 kb Distal (>10kb) Multiome 961
chr17:75,087,344–75,088,429 183.4 kb Distal (>10kb) Multiome 717
chr17:75,089,013–75,089,866 181.8 kb Distal (>10kb) Multiome 406
chr17:75,104,838–75,106,094 165.4 kb Distal (>10kb) Multiome 454
chr17:75,109,401–75,110,734 161.3 kb Distal (>10kb) Multiome 762
chr17:75,113,757–75,114,535 157.0 kb Distal (>10kb) Multiome 585
chr17:75,130,577–75,132,090 139.5 kb Distal (>10kb) Multiome 990
chr17:75,153,354–75,155,273 116.6 kb Distal (>10kb) Multiome 993
chr17:75,182,199–75,183,441 88.2 kb Distal (>10kb) Multiome 908
chr17:75,205,060–75,205,995 65.7 kb Distal (>10kb) Multiome 975
chr17:75,240,373–75,240,941 30.5 kb Distal (>10kb) Multiome 436
chr17:75,261,304–75,262,404 9.5 kb Proximal (<10kb) Multiome 983
chr17:75,267,687–75,267,942 3.2 kb Proximal (<10kb) 516
chr17:75,270,231–75,271,942 71 bp At TSS Multiome 946
chr17:75,288,761–75,289,874 18.4 kb Distal (>10kb) Multiome 941
chr17:75,346,809–75,347,324 76.0 kb Distal (>10kb) Multiome 265
chr17:75,393,479–75,394,300 122.7 kb Distal (>10kb) Multiome 834
chr17:75,404,856–75,406,161 134.6 kb Distal (>10kb) Multiome HiCAR 917
chr17:75,456,149–75,457,264 185.4 kb Distal (>10kb) Multiome 865
chr17:75,481,081–75,481,680 210.2 kb Distal (>10kb) Multiome 64
chr17:75,514,425–75,517,171 244.5 kb Distal (>10kb) Multiome 1158
chr17:75,524,764–75,527,160 254.3 kb Distal (>10kb) Multiome 951
chr17:75,549,465–75,550,388 278.8 kb Distal (>10kb) Multiome 602

Genome Browser

Genomic view of the MIF4GD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:74,962,019 – 75,560,388
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq