Involved in negative regulation of apoptotic process; positive regulation of cell migration; and positive regulation of filopodium assembly. Located in cytoplasmic side of plasma membrane and cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MIEN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MIEN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MIEN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:39,450,919–39,451,504 | 279.2 kb | Distal (>10kb) Multiome | 722 | |
| chr17:39,461,043–39,462,217 | 269.0 kb | Distal (>10kb) Multiome | 1026 | |
| chr17:39,573,453–39,574,243 | 156.7 kb | Distal (>10kb) Multiome | 520 | |
| chr17:39,636,769–39,637,600 | 93.4 kb | Distal (>10kb) Multiome | 853 | |
| chr17:39,652,588–39,653,348 | 77.5 kb | Distal (>10kb) Multiome | 263 | |
| chr17:39,668,234–39,668,690 | 62.0 kb | Distal (>10kb) Multiome | 706 | |
| chr17:39,687,710–39,688,437 | 42.5 kb | Distal (>10kb) Multiome | 800 | |
| chr17:39,695,905–39,696,636 | 34.2 kb | Distal (>10kb) Multiome | 499 | |
| chr17:39,699,516–39,700,527 | 30.6 kb | Distal (>10kb) Multiome | 528 | |
| chr17:39,730,039–39,730,906 | 20 bp | At TSS Multiome | 886 | |
| chr17:39,737,773–39,737,966 | 7.3 kb | Proximal (<10kb) | 394 | |
| chr17:39,738,118–39,738,965 | 7.6 kb | Proximal (<10kb) | 565 | |
| chr17:39,739,067–39,739,915 | 9.0 kb | Proximal (<10kb) Multiome | 648 | |
| chr17:39,740,384–39,740,910 | 10.2 kb | Distal (>10kb) Multiome | 513 | |
| chr17:39,753,811–39,754,996 | 23.9 kb | Distal (>10kb) Multiome | 1000 | |
| chr17:39,926,716–39,928,343 | 197.2 kb | Distal (>10kb) Multiome | 942 | |
| chr17:39,952,356–39,953,923 | 222.6 kb | Distal (>10kb) Multiome | 598 | |
| chr17:39,979,964–39,981,234 | 250.1 kb | Distal (>10kb) Multiome | 1148 |
Genomic view of the MIEN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.