Enables several functions, including calcium channel regulator activity; calcium ion sensor activity; and protein heterodimerization activity. Involved in calcium import into the mitochondrion; cellular response to calcium ion; and negative regulation of mitochondrial calcium ion concentration. Located in mitochondrial intermembrane space. Part of uniplex complex. Is active in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MICU2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MICU2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MICU2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:21,326,200–21,327,030 | 277.5 kb | Distal (>10kb) Multiome | 179 | |
| chr13:21,410,303–21,410,800 | 193.6 kb | Distal (>10kb) Multiome | 76 | |
| chr13:21,458,471–21,459,892 | 144.8 kb | Distal (>10kb) Multiome | 682 | |
| chr13:21,603,478–21,604,537 | 154 bp | At TSS Multiome | 918 | |
| chr13:21,669,106–21,671,240 | 66.9 kb | Distal (>10kb) Multiome | 657 | |
| chr13:21,673,391–21,674,552 | 69.8 kb | Distal (>10kb) Multiome | 365 |
Genomic view of the MICU2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.