Enables actin binding activity and molecular adaptor activity. Involved in actin filament depolymerization. Located in several cellular components, including Flemming body; intercellular bridge; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MICAL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MICAL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MICAL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:17,773,581–17,774,636 | 227.4 kb | Distal (>10kb) Multiome | 486 | |
| chr22:17,921,809–17,922,254 | 79.3 kb | Distal (>10kb) Multiome | 99 | |
| chr22:17,960,960–17,961,542 | 40.2 kb | Distal (>10kb) Multiome | 44 | |
| chr22:18,000,452–18,002,000 | 96 bp | At TSS Multiome | 878 | |
| chr22:18,023,594–18,024,038 | 22.2 kb | Distal (>10kb) Multiome | 438 | |
| chr22:18,024,279–18,024,693 | at TSS | At TSS | 425 | |
| chr22:18,077,594–18,078,615 | 76.5 kb | Distal (>10kb) Multiome | 711 | |
| chr22:18,149,651–18,150,235 | 148.4 kb | Distal (>10kb) Multiome | 573 |
Genomic view of the MICAL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.