This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Transcription factors with Perturb-seq knockdown data for MICA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MICA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MICA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:31,157,467–31,159,255 | 245.2 kb | Distal (>10kb) Multiome | 740 | |
| chr6:31,171,796–31,173,419 | 231.5 kb | Distal (>10kb) Multiome | 178 | |
| chr6:31,307,823–31,308,922 | 95.4 kb | Distal (>10kb) Multiome | 248 | |
| chr6:31,366,884–31,367,398 | 36.5 kb | Distal (>10kb) Multiome | 433 | |
| chr6:31,399,631–31,400,231 | 3.7 kb | Proximal (<10kb) Multiome | 678 | |
| chr6:31,403,046–31,404,269 | 20 bp | At TSS Multiome | 796 | |
| chr6:31,441,682–31,442,105 | 38.2 kb | Distal (>10kb) Multiome | 316 | |
| chr6:31,462,703–31,463,323 | 59.5 kb | Distal (>10kb) Multiome | 352 | |
| chr6:31,497,638–31,498,615 | 94.4 kb | Distal (>10kb) Multiome | 613 | |
| chr6:31,541,205–31,542,816 | 138.5 kb | Distal (>10kb) Multiome | 1073 | |
| chr6:31,546,485–31,547,136 | 143.2 kb | Distal (>10kb) Multiome | 589 | |
| chr6:31,547,301–31,547,742 | 144.0 kb | Distal (>10kb) Multiome | 762 | |
| chr6:31,580,713–31,581,330 | 177.4 kb | Distal (>10kb) Multiome | 745 | |
| chr6:31,619,744–31,621,435 | 216.9 kb | Distal (>10kb) Multiome | 1127 | |
| chr6:31,651,682–31,653,297 | 249.1 kb | Distal (>10kb) Multiome | 1113 | |
| chr6:31,660,325–31,660,941 | 257.2 kb | Distal (>10kb) Multiome | 892 | |
| chr6:31,664,725–31,666,373 | 261.3 kb | Distal (>10kb) Multiome | 1039 | |
| chr6:31,682,887–31,683,880 | 279.8 kb | Distal (>10kb) Multiome | 248 | |
| chr6:31,702,816–31,703,520 | 299.7 kb | Distal (>10kb) Multiome | 875 |
Genomic view of the MICA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.