MGRN1
mahogunin ring finger 1 | KIAA0544, RNF156

Enables ubiquitin-protein transferase activity. Involved in endosome to lysosome transport; negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway; and protein monoubiquitination. Located in several cellular components, including early endosome; endoplasmic reticulum; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-4
Biological processes 28 terms
cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)early endosome (GO:0005769)early endosome (GO:0005769)early endosome (GO:0005769)endosome to lysosome transport (GO:0008333)endosome to lysosome transport (GO:0008333)extracellular exosome (GO:0070062)membrane (GO:0016020)negative regulation of G protein-coupled receptor signaling pathway (GO:0045744)negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0106072)negative regulation of melanin biosynthetic process (GO:0048022)negative regulation of smoothened signaling pathway (GO:0045879)nucleus (GO:0005634)nucleus (GO:0005634)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of appetite (GO:0032100)protein binding (GO:0005515)protein monoubiquitination (GO:0006513)protein sequestering activity (GO:0140311)protein ubiquitination (GO:0016567)smoothened signaling pathway (GO:0007224)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin-protein transferase activity (GO:0004842)ubiquitin-protein transferase activity (GO:0004842)
Expression (TPM)
MGRN1 — as a Regulated Gene

TFs regulating MGRN1 0 TFs

Transcription factors with Perturb-seq knockdown data for MGRN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MGRN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to MGRN1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MGRN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:4,327,446–4,328,634 288.2 kb Distal (>10kb) Multiome 495
chr16:4,350,579–4,351,773 265.1 kb Distal (>10kb) Multiome 674
chr16:4,371,473–4,372,791 244.7 kb Distal (>10kb) Multiome 617
chr16:4,402,485–4,403,104 213.7 kb Distal (>10kb) Multiome 450
chr16:4,415,818–4,417,201 199.8 kb Distal (>10kb) Multiome 681
chr16:4,425,392–4,426,322 190.8 kb Distal (>10kb) Multiome 881
chr16:4,474,111–4,474,929 141.9 kb Distal (>10kb) Multiome 626
chr16:4,476,027–4,477,237 140.1 kb Distal (>10kb) Multiome 841
chr16:4,537,639–4,538,998 77.8 kb Distal (>10kb) Multiome HiCAR 1087
chr16:4,585,331–4,585,992 30.8 kb Distal (>10kb) Multiome 223
chr16:4,613,912–4,617,164 1.6 kb Proximal (<10kb) Multiome 1079
chr16:4,624,301–4,625,703 8.2 kb Proximal (<10kb) Multiome 866
chr16:4,693,016–4,694,663 77.1 kb Distal (>10kb) Multiome 730
chr16:4,733,836–4,735,221 117.9 kb Distal (>10kb) Multiome 858
chr16:4,766,728–4,767,628 150.8 kb Distal (>10kb) Multiome 795
chr16:4,768,438–4,769,162 152.3 kb Distal (>10kb) Multiome 677
chr16:4,801,836–4,803,175 185.8 kb Distal (>10kb) Multiome 743
chr16:4,846,559–4,848,209 230.9 kb Distal (>10kb) Multiome 803

Genome Browser

Genomic view of the MGRN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:4,317,446 – 4,858,209
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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