Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MFSD6L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MFSD6L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MFSD6L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:8,584,054–8,584,700 | 215.0 kb | Distal (>10kb) Multiome | 18 | |
| chr17:8,629,690–8,631,825 | 168.3 kb | Distal (>10kb) Multiome | 878 | |
| chr17:8,745,813–8,746,432 | 53.2 kb | Distal (>10kb) Multiome | 522 | |
| chr17:8,799,086–8,799,614 | 9 bp | At TSS Multiome | 168 | |
| chr17:8,874,228–8,874,922 | 75.1 kb | Distal (>10kb) Multiome | 46 | |
| chr17:8,875,038–8,875,633 | 75.9 kb | Distal (>10kb) Multiome | 15 | |
| chr17:8,965,232–8,966,153 | 166.4 kb | Distal (>10kb) Multiome | 326 | |
| chr17:9,016,631–9,018,085 | 217.9 kb | Distal (>10kb) Multiome | 402 | |
| chr17:9,020,838–9,022,766 | 222.1 kb | Distal (>10kb) Multiome | 376 | |
| chr17:9,537,200–9,537,700 | 738.1 kb | Distal (>10kb) Multiome HiCAR | 104 | |
| chr17:9,538,516–9,539,118 | 739.5 kb | Distal (>10kb) Multiome HiCAR | 40 |
Genomic view of the MFSD6L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.