Predicted to enable MHC class I protein binding activity and MHC class I receptor activity. Predicted to be involved in antigen processing and presentation of exogenous peptide antigen via MHC class I. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MFSD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MFSD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MFSD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:190,119,022–190,119,699 | 288.9 kb | Distal (>10kb) Multiome | 98 | |
| chr2:190,179,802–190,181,497 | 227.8 kb | Distal (>10kb) Multiome | 911 | |
| chr2:190,319,052–190,320,177 | 88.5 kb | Distal (>10kb) Multiome | 934 | |
| chr2:190,343,052–190,344,699 | 64.4 kb | Distal (>10kb) Multiome | 922 | |
| chr2:190,404,471–190,404,812 | 3.5 kb | Proximal (<10kb) | 172 | |
| chr2:190,407,333–190,409,184 | 28 bp | At TSS Multiome | 669 | |
| chr2:190,413,054–190,413,329 | 4.7 kb | Proximal (<10kb) | 18 | |
| chr2:190,533,850–190,535,346 | 126.3 kb | Distal (>10kb) Multiome | 1040 | |
| chr2:190,647,806–190,650,037 | 240.7 kb | Distal (>10kb) Multiome | 864 | |
| chr2:190,679,871–190,680,604 | 272.0 kb | Distal (>10kb) Multiome | 345 |
Genomic view of the MFSD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.