Enables mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in mRNA destabilization and mRNA localization resulting in post-transcriptional regulation of gene expression. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MEX3D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEX3D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEX3D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:1,265,280–1,270,235 | 299.0 kb | Distal (>10kb) Multiome | 1171 | |
| chr19:1,274,423–1,276,502 | 292.6 kb | Distal (>10kb) Multiome | 967 | |
| chr19:1,285,317–1,286,108 | 282.5 kb | Distal (>10kb) Multiome | 277 | |
| chr19:1,354,303–1,355,411 | 213.4 kb | Distal (>10kb) Multiome | 688 | |
| chr19:1,383,122–1,384,333 | 184.7 kb | Distal (>10kb) Multiome | 1228 | |
| chr19:1,401,101–1,401,839 | 166.8 kb | Distal (>10kb) Multiome | 540 | |
| chr19:1,406,589–1,408,783 | 160.9 kb | Distal (>10kb) Multiome | 911 | |
| chr19:1,415,008–1,415,721 | 152.8 kb | Distal (>10kb) Multiome | 597 | |
| chr19:1,437,988–1,438,998 | 130.0 kb | Distal (>10kb) Multiome | 1076 | |
| chr19:1,444,785–1,447,383 | 123.1 kb | Distal (>10kb) Multiome | 797 | |
| chr19:1,455,191–1,456,421 | 112.5 kb | Distal (>10kb) Multiome | 491 | |
| chr19:1,468,941–1,469,903 | 99.0 kb | Distal (>10kb) Multiome | 242 | |
| chr19:1,470,088–1,471,597 | 97.6 kb | Distal (>10kb) Multiome | 544 | |
| chr19:1,478,772–1,479,848 | 89.0 kb | Distal (>10kb) Multiome | 857 | |
| chr19:1,489,566–1,491,829 | 77.4 kb | Distal (>10kb) Multiome | 836 | |
| chr19:1,507,230–1,508,699 | 60.2 kb | Distal (>10kb) Multiome | 596 | |
| chr19:1,512,960–1,513,686 | 55.1 kb | Distal (>10kb) Multiome | 541 | |
| chr19:1,523,798–1,524,624 | 44.3 kb | Distal (>10kb) Multiome | 263 | |
| chr19:1,566,277–1,568,916 | 1.6 kb | Proximal (<10kb) Multiome | 748 | |
| chr19:1,592,085–1,593,444 | 24.4 kb | Distal (>10kb) Multiome | 883 | |
| chr19:1,604,859–1,606,501 | 37.3 kb | Distal (>10kb) Multiome | 902 | |
| chr19:1,651,519–1,653,514 | 84.6 kb | Distal (>10kb) Multiome | 909 | |
| chr19:1,725,307–1,726,101 | 157.4 kb | Distal (>10kb) Multiome | 455 | |
| chr19:1,811,638–1,813,347 | 244.3 kb | Distal (>10kb) Multiome | 782 | |
| chr19:1,826,853–1,827,379 | 258.9 kb | Distal (>10kb) Multiome | 193 | |
| chr19:1,848,048–1,848,953 | 280.3 kb | Distal (>10kb) Multiome | 819 | |
| chr19:1,851,701–1,852,216 | 283.6 kb | Distal (>10kb) Multiome | 115 | |
| chr19:1,855,082–1,856,620 | 287.2 kb | Distal (>10kb) Multiome | 476 | |
| chr19:1,861,439–1,865,723 | 295.6 kb | Distal (>10kb) Multiome | 891 |
Genomic view of the MEX3D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.