The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MELTF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MELTF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MELTF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:196,739,555–196,740,517 | 289.9 kb | Distal (>10kb) Multiome | 736 | |
| chr3:196,867,462–196,868,618 | 162.0 kb | Distal (>10kb) Multiome | 794 | |
| chr3:196,941,814–196,943,294 | 87.3 kb | Distal (>10kb) Multiome | 1027 | |
| chr3:196,968,365–196,969,147 | 61.1 kb | Distal (>10kb) Multiome | 597 | |
| chr3:196,969,208–196,970,172 | 59.8 kb | Distal (>10kb) Multiome | 714 | |
| chr3:197,002,398–197,004,003 | 26.7 kb | Distal (>10kb) Multiome HiCAR | 569 | |
| chr3:197,028,743–197,030,204 | 31 bp | At TSS Multiome | 646 | |
| chr3:197,297,490–197,299,437 | 268.5 kb | Distal (>10kb) Multiome | 941 | |
| chr3:197,464,855–197,465,525 | 435.3 kb | Distal (>10kb) Multiome HiCAR | 302 | |
| chr3:197,509,884–197,510,593 | 480.5 kb | Distal (>10kb) Multiome HiCAR | 656 | |
| chr3:197,527,591–197,529,092 | 498.5 kb | Distal (>10kb) Multiome HiCAR | 184 |
Genomic view of the MELTF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.