Transcription factors with Perturb-seq knockdown data for MEF2C-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MEF2C-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MEF2C-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:88,659,646–88,661,615 | 228.2 kb | Distal (>10kb) Multiome | 570 | |
| chr5:88,671,570–88,672,534 | 217.2 kb | Distal (>10kb) Multiome | 221 | |
| chr5:88,674,048–88,676,457 | 213.2 kb | Distal (>10kb) Multiome | 679 | |
| chr5:88,680,113–88,681,161 | 208.7 kb | Distal (>10kb) Multiome | 559 | |
| chr5:88,684,266–88,685,701 | 204.3 kb | Distal (>10kb) Multiome | 236 | |
| chr5:88,882,818–88,884,745 | 5.9 kb | Proximal (<10kb) Multiome | 663 | |
| chr5:88,889,081–88,890,131 | at TSS | At TSS | 433 | |
| chr5:88,897,693–88,898,089 | 8.4 kb | Proximal (<10kb) | 66 |
Genomic view of the MEF2C-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.