Enables nuclear thyroid hormone receptor binding activity and transcription coactivator activity. Involved in positive regulation of transcription initiation by RNA polymerase II. Located in nucleus. Part of core mediator complex and mediator complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MED16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MED16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MED16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:632,653–633,806 | 259.6 kb | Distal (>10kb) Multiome | 758 | |
| chr19:639,456–640,331 | 253.4 kb | Distal (>10kb) Multiome | 389 | |
| chr19:662,267–663,864 | 229.9 kb | Distal (>10kb) Multiome | 723 | |
| chr19:679,616–681,731 | 212.5 kb | Distal (>10kb) Multiome | 832 | |
| chr19:703,387–704,718 | 189.2 kb | Distal (>10kb) Multiome | 586 | |
| chr19:708,425–709,293 | 184.4 kb | Distal (>10kb) Multiome | 317 | |
| chr19:796,668–798,362 | 96.0 kb | Distal (>10kb) Multiome | 956 | |
| chr19:821,294–822,728 | 71.0 kb | Distal (>10kb) Multiome | 254 | |
| chr19:861,664–863,223 | 31.0 kb | Distal (>10kb) Multiome | 530 | |
| chr19:892,703–893,746 | 20 bp | At TSS Multiome | 715 | |
| chr19:917,038–918,169 | 24.6 kb | Distal (>10kb) Multiome | 711 | |
| chr19:924,743–926,242 | 32.5 kb | Distal (>10kb) Multiome | 796 | |
| chr19:927,058–927,629 | 34.2 kb | Distal (>10kb) Multiome | 362 | |
| chr19:982,565–983,215 | 89.6 kb | Distal (>10kb) Multiome | 590 | |
| chr19:984,046–985,154 | 91.3 kb | Distal (>10kb) Multiome | 829 | |
| chr19:1,000,142–1,000,881 | 107.2 kb | Distal (>10kb) Multiome | 399 | |
| chr19:1,020,611–1,022,069 | 128.2 kb | Distal (>10kb) Multiome | 1017 | |
| chr19:1,026,155–1,026,856 | 133.3 kb | Distal (>10kb) Multiome | 598 | |
| chr19:1,027,770–1,028,926 | 135.4 kb | Distal (>10kb) Multiome | 584 | |
| chr19:1,039,648–1,040,400 | 146.8 kb | Distal (>10kb) Multiome | 684 | |
| chr19:1,040,481–1,041,402 | 148.0 kb | Distal (>10kb) Multiome | 556 | |
| chr19:1,044,758–1,045,598 | 152.1 kb | Distal (>10kb) Multiome | 402 | |
| chr19:1,061,840–1,062,923 | 169.4 kb | Distal (>10kb) Multiome | 204 | |
| chr19:1,063,045–1,065,722 | 171.6 kb | Distal (>10kb) Multiome | 681 | |
| chr19:1,066,682–1,067,587 | 174.0 kb | Distal (>10kb) Multiome | 489 | |
| chr19:1,071,107–1,071,721 | 177.9 kb | Distal (>10kb) Multiome | 178 | |
| chr19:1,081,317–1,083,172 | 189.2 kb | Distal (>10kb) Multiome | 484 | |
| chr19:1,094,985–1,095,654 | 202.3 kb | Distal (>10kb) Multiome | 671 | |
| chr19:1,103,487–1,105,654 | 210.8 kb | Distal (>10kb) Multiome | 849 | |
| chr19:1,112,029–1,112,884 | 219.1 kb | Distal (>10kb) Multiome | 294 | |
| chr19:1,113,014–1,114,139 | 220.4 kb | Distal (>10kb) Multiome | 690 | |
| chr19:1,122,934–1,123,720 | 230.0 kb | Distal (>10kb) Multiome | 231 | |
| chr19:1,173,441–1,174,438 | 281.0 kb | Distal (>10kb) Multiome | 682 |
Genomic view of the MED16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.