The protein encoded by this gene is an oxidoreductase that catalyzes the last step in mitochondrial fatty acid synthesis. Defects in this gene are a cause of childhood-onset dystonia and optic atrophy. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for MECR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MECR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MECR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:29,120,877–29,125,914 | 108.5 kb | Distal (>10kb) Multiome | 782 | |
| chr1:29,181,113–29,182,382 | 49.0 kb | Distal (>10kb) Multiome | 1028 | |
| chr1:29,230,591–29,231,321 | 18 bp | At TSS Multiome | 779 | |
| chr1:29,236,103–29,236,982 | 5.5 kb | Proximal (<10kb) Multiome | 621 | |
| chr1:29,237,419–29,238,642 | 6.5 kb | Proximal (<10kb) | 536 | |
| chr1:29,240,411–29,240,750 | 9.5 kb | Proximal (<10kb) | 71 | |
| chr1:29,249,179–29,249,843 | 18.5 kb | Distal (>10kb) Multiome | 238 | |
| chr1:29,259,283–29,260,756 | 29.1 kb | Distal (>10kb) Multiome | 310 | |
| chr1:29,282,701–29,284,079 | 52.3 kb | Distal (>10kb) Multiome | 308 | |
| chr1:29,324,465–29,325,612 | 94.0 kb | Distal (>10kb) Multiome | 180 | |
| chr1:30,085,760–30,086,457 | 855.2 kb | Distal (>10kb) Multiome HiCAR | 209 | |
| chr1:30,242,642–30,243,684 | 1012.2 kb | Distal (>10kb) Multiome HiCAR | 156 | |
| chr1:30,685,020–30,686,083 | 1454.5 kb | Distal (>10kb) Multiome HiCAR | 317 | |
| chr1:30,690,022–30,690,694 | 1459.4 kb | Distal (>10kb) Multiome HiCAR | 35 | |
| chr1:30,717,727–30,719,875 | 1487.5 kb | Distal (>10kb) Multiome HiCAR | 1003 | |
| chr1:30,837,666–30,838,184 | 1606.9 kb | Distal (>10kb) Multiome HiCAR | 67 |
Genomic view of the MECR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.