This gene encodes a microtubule-binding nuclear protein that localizes to the centrioles of dividing cells and differentiating multiciliated cells and negatively regulates centriole duplication. The encoded protein is closely associated with the centriole barrel, and resides in the centriole lumen. Naturally-occurring mutations in the orthologous mouse gene are associated with age-related retinal degeneration. [provided by RefSeq, Feb 2019]
Transcription factors with Perturb-seq knockdown data for MDM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MDM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MDM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:68,203,390–68,203,915 | 128.8 kb | Distal (>10kb) Multiome | 81 | |
| chr12:68,331,875–68,332,795 | 37 bp | At TSS Multiome | 616 | |
| chr12:68,365,008–68,365,679 | 33.0 kb | Distal (>10kb) Multiome | 731 | |
| chr12:68,538,810–68,539,554 | 206.7 kb | Distal (>10kb) Multiome | 347 | |
| chr12:68,610,127–68,611,767 | 278.4 kb | Distal (>10kb) Multiome HiCAR | 846 | |
| chr12:68,686,562–68,687,457 | 354.5 kb | Distal (>10kb) Multiome HiCAR | 987 |
Genomic view of the MDM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.