Enables calcium ion binding activity. Predicted to be involved in several processes, including modulation of chemical synaptic transmission; negative regulation of endocytosis; and negative regulation of response to oxidative stress. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MCTP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MCTP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MCTP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:95,177,807–95,178,757 | 105.7 kb | Distal (>10kb) Multiome | 321 | |
| chr5:95,281,138–95,281,615 | 2.4 kb | Proximal (<10kb) | 146 | |
| chr5:95,283,233–95,285,856 | 258 bp | At TSS Multiome | 620 | |
| chr5:95,439,846–95,441,190 | 156.3 kb | Distal (>10kb) Multiome | 213 | |
| chr5:95,554,418–95,555,610 | 271.1 kb | Distal (>10kb) Multiome | 886 |
Genomic view of the MCTP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.