This gene encodes a member of the geminin family of proteins. The encoded nuclear protein is required for the generation of multiciliated cells in respiratory epithelium. Mutations in this gene cause a rare mucociliary clearance disorder associated with recurring respiratory infections in human patients, known as reduced generation of multiple motile cilia (RGMC). [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for MCIDAS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MCIDAS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MCIDAS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:55,219,099–55,219,255 | 8.0 kb | Proximal (<10kb) | 151 | |
| chr5:55,220,318–55,221,200 | 6.1 kb | Proximal (<10kb) | 183 | |
| chr5:55,223,205–55,223,845 | 3.4 kb | Proximal (<10kb) | 79 | |
| chr5:55,226,323–55,227,998 | at TSS | At TSS | 708 | |
| chr5:55,232,241–55,234,359 | 5.0 kb | Proximal (<10kb) | 615 |
Genomic view of the MCIDAS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.