The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for MCAT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MCAT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MCAT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:42,856,601–42,857,716 | 286.1 kb | Distal (>10kb) Multiome | 938 | |
| chr22:42,964,987–42,965,486 | 178.2 kb | Distal (>10kb) Multiome | 332 | |
| chr22:43,014,433–43,015,934 | 128.1 kb | Distal (>10kb) Multiome | 845 | |
| chr22:43,089,058–43,089,753 | 54.0 kb | Distal (>10kb) Multiome | 726 | |
| chr22:43,110,485–43,111,495 | 32.6 kb | Distal (>10kb) Multiome | 485 | |
| chr22:43,142,895–43,143,571 | 7 bp | At TSS Multiome | 810 | |
| chr22:43,151,300–43,151,927 | 8.2 kb | Proximal (<10kb) Multiome | 340 | |
| chr22:43,187,421–43,188,123 | 44.2 kb | Distal (>10kb) Multiome | 819 | |
| chr22:43,216,557–43,217,579 | 73.6 kb | Distal (>10kb) Multiome | 90 | |
| chr22:43,226,308–43,226,848 | 83.2 kb | Distal (>10kb) Multiome | 56 | |
| chr22:43,231,079–43,231,533 | 88.0 kb | Distal (>10kb) Multiome | 240 | |
| chr22:43,343,283–43,343,875 | 200.1 kb | Distal (>10kb) Multiome | 205 |
Genomic view of the MCAT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.