The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MATK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MATK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MATK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:3,500,403–3,501,074 | 285.2 kb | Distal (>10kb) Multiome | 886 | |
| chr19:3,505,575–3,507,061 | 279.9 kb | Distal (>10kb) Multiome | 838 | |
| chr19:3,557,019–3,558,238 | 228.3 kb | Distal (>10kb) Multiome | 811 | |
| chr19:3,572,147–3,574,664 | 211.9 kb | Distal (>10kb) Multiome | 737 | |
| chr19:3,576,363–3,578,543 | 208.9 kb | Distal (>10kb) Multiome | 346 | |
| chr19:3,606,342–3,607,177 | 179.2 kb | Distal (>10kb) Multiome | 377 | |
| chr19:3,626,518–3,627,304 | 159.0 kb | Distal (>10kb) Multiome | 833 | |
| chr19:3,699,968–3,700,899 | 85.5 kb | Distal (>10kb) Multiome | 489 | |
| chr19:3,721,462–3,721,997 | 64.4 kb | Distal (>10kb) Multiome | 760 | |
| chr19:3,722,652–3,723,093 | 63.1 kb | Distal (>10kb) Multiome | 106 | |
| chr19:3,761,103–3,762,150 | 24.4 kb | Distal (>10kb) Multiome | 839 | |
| chr19:3,762,300–3,763,344 | 23.1 kb | Distal (>10kb) Multiome | 817 | |
| chr19:3,786,012–3,786,456 | at TSS | At TSS | 237 | |
| chr19:3,868,451–3,869,181 | 83.1 kb | Distal (>10kb) Multiome | 233 | |
| chr19:3,932,937–3,933,664 | 147.3 kb | Distal (>10kb) Multiome | 198 | |
| chr19:3,968,623–3,969,280 | 182.8 kb | Distal (>10kb) Multiome | 547 | |
| chr19:3,970,535–3,971,713 | 185.2 kb | Distal (>10kb) Multiome | 728 | |
| chr19:3,985,032–3,985,862 | 199.4 kb | Distal (>10kb) Multiome | 932 | |
| chr19:4,006,992–4,008,553 | 221.6 kb | Distal (>10kb) Multiome | 888 | |
| chr19:4,064,058–4,067,782 | 279.9 kb | Distal (>10kb) Multiome | 811 |
Genomic view of the MATK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.