The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for MAT2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAT2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAT2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:163,273,656–163,274,943 | 229.0 kb | Distal (>10kb) Multiome | 149 | |
| chr5:163,330,258–163,331,560 | 172.2 kb | Distal (>10kb) Multiome | 240 | |
| chr5:163,334,244–163,334,828 | 168.7 kb | Distal (>10kb) Multiome | 66 | |
| chr5:163,340,037–163,340,700 | 162.9 kb | Distal (>10kb) Multiome | 37 | |
| chr5:163,432,842–163,434,227 | 69.8 kb | Distal (>10kb) Multiome | 173 | |
| chr5:163,437,029–163,438,386 | 65.7 kb | Distal (>10kb) Multiome | 946 | |
| chr5:163,459,472–163,462,155 | 42.9 kb | Distal (>10kb) Multiome | 1131 | |
| chr5:163,502,571–163,503,862 | 7 bp | At TSS Multiome | 479 | |
| chr5:163,503,971–163,504,311 | 739 bp | At TSS | 138 | |
| chr5:163,504,412–163,504,964 | 1.2 kb | Proximal (<10kb) | 345 | |
| chr5:163,505,139–163,506,032 | 2.4 kb | Proximal (<10kb) Multiome | 889 | |
| chr5:163,509,378–163,509,598 | 6.1 kb | Proximal (<10kb) | 147 | |
| chr5:163,531,300–163,534,247 | 28.3 kb | Distal (>10kb) Multiome | 391 |
Genomic view of the MAT2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.