MAST1

microtubule associated serine/threonine kinase 1 | KIAA0973, SAST

This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system. [provided by RefSeq, May 2017]

Biological processes 33 terms

ATP binding (GO:0005524)ATP binding (GO:0005524)axon (GO:0030424)brain development (GO:0007420)brain development (GO:0007420)brain development (GO:0007420)cytoskeleton (GO:0005856)cytoskeleton organization (GO:0007010)cytoskeleton organization (GO:0007010)cytoskeleton organization (GO:0007010)dendrite (GO:0030425)developmental process (GO:0032502)intracellular signal transduction (GO:0035556)intracellular signal transduction (GO:0035556)magnesium ion binding (GO:0000287)magnesium ion binding (GO:0000287)membrane (GO:0016020)microtubule binding (GO:0008017)microtubule binding (GO:0008017)microtubule cytoskeleton (GO:0015630)neuron projection (GO:0043005)neuron projection (GO:0043005)neuronal cell body (GO:0043025)neuronal cell body (GO:0043025)neuronal cell body (GO:0043025)plasma membrane (GO:0005886)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein phosphorylation (GO:0006468)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)protein serine/threonine kinase activity (GO:0004674)

Expression (TPM)

TFs regulating MAST1 0 TFs

Transcription factors with Perturb-seq knockdown data for MAST1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAST1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MAST1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAST1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:12,550,951–12,551,971	282.4 kb	Distal (>10kb) Multiome	976
chr19:12,571,455–12,571,942	262.3 kb	Distal (>10kb) Multiome	36
chr19:12,610,516–12,611,613	223.0 kb	Distal (>10kb) Multiome	925
chr19:12,639,899–12,640,614	193.7 kb	Distal (>10kb) Multiome	454
chr19:12,647,538–12,648,022	186.2 kb	Distal (>10kb) Multiome	126
chr19:12,656,871–12,657,566	176.8 kb	Distal (>10kb) Multiome	254
chr19:12,666,317–12,667,225	167.2 kb	Distal (>10kb) Multiome	495
chr19:12,669,351–12,669,939	164.4 kb	Distal (>10kb) Multiome	777
chr19:12,681,003–12,682,117	152.5 kb	Distal (>10kb) Multiome	994
chr19:12,696,035–12,696,970	137.3 kb	Distal (>10kb) Multiome	806
chr19:12,702,968–12,703,602	130.7 kb	Distal (>10kb) Multiome	121
chr19:12,721,692–12,723,084	111.5 kb	Distal (>10kb) Multiome	807
chr19:12,723,726–12,724,142	109.9 kb	Distal (>10kb) Multiome	539
chr19:12,734,221–12,735,284	99.2 kb	Distal (>10kb) Multiome	882
chr19:12,736,470–12,737,780	96.8 kb	Distal (>10kb) Multiome	742
chr19:12,757,454–12,758,297	76.2 kb	Distal (>10kb) Multiome	588
chr19:12,765,876–12,766,545	67.7 kb	Distal (>10kb) Multiome	557
chr19:12,774,659–12,776,025	58.5 kb	Distal (>10kb) Multiome	803
chr19:12,777,481–12,778,589	56.1 kb	Distal (>10kb) Multiome	661
chr19:12,782,418–12,783,038	51.2 kb	Distal (>10kb) Multiome	699
chr19:12,789,543–12,790,654	43.9 kb	Distal (>10kb) Multiome	717
chr19:12,790,960–12,793,231	42.4 kb	Distal (>10kb) Multiome	1015
chr19:12,793,340–12,794,240	40.2 kb	Distal (>10kb) Multiome	808
chr19:12,801,120–12,802,290	32.0 kb	Distal (>10kb) Multiome	901
chr19:12,806,212–12,806,984	27.4 kb	Distal (>10kb) Multiome	827
chr19:12,825,565–12,826,186	8.1 kb	Proximal (<10kb) Multiome	436
chr19:12,828,495–12,828,851	5.1 kb	Proximal (<10kb)	216
chr19:12,832,484–12,833,101	1.3 kb	Proximal (<10kb) Multiome	970
chr19:12,833,638–12,834,477	13 bp	At TSS Multiome	310
chr19:12,835,367–12,835,598	1.4 kb	Proximal (<10kb)	156
chr19:12,836,309–12,836,604	2.4 kb	Proximal (<10kb)	484
chr19:12,838,114–12,838,869	4.5 kb	Proximal (<10kb) Multiome	377
chr19:12,840,071–12,841,485	6.9 kb	Proximal (<10kb) Multiome	391
chr19:12,847,633–12,848,090	13.8 kb	Distal (>10kb) Multiome	535
chr19:12,867,327–12,868,022	33.7 kb	Distal (>10kb) Multiome	315
chr19:12,872,968–12,873,990	39.4 kb	Distal (>10kb) Multiome	263
chr19:12,880,834–12,881,875	47.5 kb	Distal (>10kb) Multiome	656
chr19:12,884,836–12,886,381	51.4 kb	Distal (>10kb) Multiome	717
chr19:12,890,614–12,891,603	57.1 kb	Distal (>10kb) Multiome	841
chr19:12,913,054–12,913,584	79.4 kb	Distal (>10kb) Multiome	373
chr19:12,919,018–12,919,719	85.4 kb	Distal (>10kb) Multiome	732
chr19:12,933,441–12,934,086	99.8 kb	Distal (>10kb) Multiome	789
chr19:12,937,426–12,939,166	104.5 kb	Distal (>10kb) Multiome	943
chr19:12,945,275–12,946,647	112.0 kb	Distal (>10kb) Multiome	1015
chr19:12,956,801–12,957,360	123.3 kb	Distal (>10kb) Multiome	747
chr19:12,964,998–12,965,862	131.5 kb	Distal (>10kb) Multiome	733
chr19:12,983,506–12,983,997	149.7 kb	Distal (>10kb) Multiome	688
chr19:13,051,485–13,052,169	217.9 kb	Distal (>10kb) Multiome	649
chr19:13,061,195–13,061,672	227.5 kb	Distal (>10kb) Multiome	544
chr19:13,069,469–13,070,306	235.9 kb	Distal (>10kb) Multiome	334
chr19:13,093,620–13,094,260	260.0 kb	Distal (>10kb) Multiome	411
chr19:13,095,079–13,096,870	261.5 kb	Distal (>10kb) Multiome	501
chr19:13,102,495–13,103,074	268.9 kb	Distal (>10kb) Multiome	606
chr19:13,116,411–13,117,080	282.8 kb	Distal (>10kb) Multiome	812
chr19:13,117,979–13,119,416	284.3 kb	Distal (>10kb) Multiome	699

Genome Browser

Genomic view of the MAST1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.