Predicted to be a structural constituent of myelin sheath. Predicted to be involved in myelination. Predicted to be located in several cellular components, including cytoskeleton; nucleus; and plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MARVELD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MARVELD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MARVELD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:97,418,830–97,419,461 | 294.6 kb | Distal (>10kb) Multiome | 323 | |
| chr10:97,425,050–97,426,796 | 287.6 kb | Distal (>10kb) Multiome | 715 | |
| chr10:97,445,521–97,446,585 | 267.6 kb | Distal (>10kb) Multiome | 802 | |
| chr10:97,497,718–97,499,773 | 215.0 kb | Distal (>10kb) Multiome | 967 | |
| chr10:97,553,598–97,554,047 | 160.0 kb | Distal (>10kb) Multiome | 340 | |
| chr10:97,632,775–97,633,915 | 80.3 kb | Distal (>10kb) Multiome | 725 | |
| chr10:97,640,236–97,641,335 | 73.1 kb | Distal (>10kb) Multiome | 712 | |
| chr10:97,686,724–97,687,987 | 26.3 kb | Distal (>10kb) Multiome | 993 | |
| chr10:97,713,223–97,715,263 | 45 bp | At TSS Multiome | 639 | |
| chr10:97,736,595–97,737,824 | 23.4 kb | Distal (>10kb) Multiome | 1009 | |
| chr10:97,771,123–97,772,389 | 58.0 kb | Distal (>10kb) Multiome | 356 | |
| chr10:97,788,725–97,789,448 | 75.4 kb | Distal (>10kb) Multiome | 398 | |
| chr10:97,849,566–97,850,474 | 136.3 kb | Distal (>10kb) Multiome | 400 | |
| chr10:97,857,830–97,858,402 | 144.3 kb | Distal (>10kb) Multiome | 160 | |
| chr10:97,869,190–97,869,924 | 155.8 kb | Distal (>10kb) Multiome | 506 |
Genomic view of the MARVELD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.