This gene produces a mitochondrial methionyl-tRNA synthetase protein that is encoded by the nuclear genome and imported to the mitochondrion. This protein likely functions as a monomer and is predicted to localize to the mitochondrial matrix. Mutations in this gene are associated with the autosomal recessive neurodegenerative disease spastic ataxia-3 (SPAX3). [provided by RefSeq, Apr 2014]
Transcription factors with Perturb-seq knockdown data for MARS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MARS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MARS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:197,434,572–197,435,653 | 270.3 kb | Distal (>10kb) Multiome HiCAR | 937 | |
| chr2:197,452,830–197,454,321 | 252.0 kb | Distal (>10kb) Multiome | 1033 | |
| chr2:197,498,722–197,500,854 | 205.3 kb | Distal (>10kb) Multiome HiCAR | 1173 | |
| chr2:197,515,482–197,516,752 | 189.3 kb | Distal (>10kb) Multiome | 1138 | |
| chr2:197,586,916–197,587,749 | 117.9 kb | Distal (>10kb) Multiome | 118 | |
| chr2:197,704,733–197,706,212 | 24 bp | At TSS Multiome | 870 | |
| chr2:197,706,311–197,706,995 | 943 bp | At TSS | 162 | |
| chr2:197,707,306–197,707,853 | 1.9 kb | Proximal (<10kb) | 177 | |
| chr2:197,785,007–197,786,878 | 80.9 kb | Distal (>10kb) Multiome | 322 | |
| chr2:197,804,172–197,805,545 | 99.2 kb | Distal (>10kb) Multiome | 556 |
Genomic view of the MARS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.