Enables several functions, including ATP binding activity; magnesium ion binding activity; and phospholipid binding activity. Involved in intracellular signal transduction; negative regulation of epithelial to mesenchymal transition; and protein phosphorylation. Located in cytoplasm; dendrite; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MARK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MARK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MARK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:220,271,709–220,273,089 | 255.7 kb | Distal (>10kb) Multiome | 984 | |
| chr1:220,338,584–220,339,585 | 189.2 kb | Distal (>10kb) Multiome | 180 | |
| chr1:220,526,400–220,526,628 | 1.5 kb | Proximal (<10kb) | 55 | |
| chr1:220,527,225–220,529,488 | 147 bp | At TSS Multiome | 617 | |
| chr1:220,689,932–220,691,083 | 162.2 kb | Distal (>10kb) Multiome | 763 | |
| chr1:220,733,095–220,733,546 | 205.1 kb | Distal (>10kb) Multiome | 459 | |
| chr1:220,747,474–220,749,068 | 220.2 kb | Distal (>10kb) Multiome | 799 | |
| chr1:220,785,886–220,787,782 | 258.9 kb | Distal (>10kb) Multiome | 800 | |
| chr1:220,809,823–220,810,852 | 282.3 kb | Distal (>10kb) Multiome | 265 |
Genomic view of the MARK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.