This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for MAPKBP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAPKBP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAPKBP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:41,493,120–41,493,918 | 280.8 kb | Distal (>10kb) Multiome | 692 | |
| chr15:41,543,905–41,544,403 | 230.3 kb | Distal (>10kb) Multiome | 687 | |
| chr15:41,558,746–41,559,337 | 215.3 kb | Distal (>10kb) Multiome | 358 | |
| chr15:41,621,149–41,622,233 | 152.7 kb | Distal (>10kb) Multiome | 998 | |
| chr15:41,636,747–41,637,351 | 137.4 kb | Distal (>10kb) Multiome | 46 | |
| chr15:41,659,914–41,660,957 | 114.1 kb | Distal (>10kb) Multiome | 850 | |
| chr15:41,774,030–41,774,948 | 15 bp | At TSS Multiome | 944 | |
| chr15:41,827,735–41,828,567 | 53.6 kb | Distal (>10kb) Multiome | 635 | |
| chr15:41,971,929–41,972,919 | 198.2 kb | Distal (>10kb) Multiome | 740 |
Genomic view of the MAPKBP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.