Transcription factors with Perturb-seq knockdown data for MAPKAPK5-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAPKAPK5-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAPKAPK5-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:111,597,725–111,600,125 | 242.4 kb | Distal (>10kb) Multiome | 973 | |
| chr12:111,685,452–111,686,504 | 155.9 kb | Distal (>10kb) Multiome | 858 | |
| chr12:111,766,539–111,767,436 | 75.0 kb | Distal (>10kb) Multiome | 732 | |
| chr12:111,775,668–111,776,178 | 66.0 kb | Distal (>10kb) Multiome | 448 | |
| chr12:111,841,636–111,842,766 | 126 bp | At TSS Multiome | 963 | |
| chr12:111,967,710–111,968,344 | 126.1 kb | Distal (>10kb) Multiome | 26 | |
| chr12:112,012,418–112,014,496 | 171.3 kb | Distal (>10kb) Multiome | 1077 | |
| chr12:112,108,135–112,109,541 | 266.8 kb | Distal (>10kb) Multiome | 788 | |
| chr12:112,116,420–112,116,883 | 274.8 kb | Distal (>10kb) Multiome | 549 | |
| chr12:112,125,273–112,125,989 | 283.5 kb | Distal (>10kb) Multiome | 798 |
Genomic view of the MAPKAPK5-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.