This gene encodes a member of the Ser/Thr protein kinase family. This kinase is regulated through direct phosphorylation by p38 MAP kinase. In conjunction with p38 MAP kinase, this kinase is known to be involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation. Heat shock protein HSP27 was shown to be one of the substrates of this kinase in vivo. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAPKAPK2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAPKAPK2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAPKAPK2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:206,490,111–206,490,584 | 194.6 kb | Distal (>10kb) Multiome | 320 | |
| chr1:206,506,880–206,508,298 | 177.4 kb | Distal (>10kb) Multiome | 469 | |
| chr1:206,544,602–206,545,089 | 140.0 kb | Distal (>10kb) Multiome | 336 | |
| chr1:206,556,960–206,557,656 | 127.6 kb | Distal (>10kb) Multiome | 540 | |
| chr1:206,612,122–206,612,956 | 72.4 kb | Distal (>10kb) Multiome | 1157 | |
| chr1:206,634,849–206,636,243 | 49.4 kb | Distal (>10kb) Multiome | 899 | |
| chr1:206,658,246–206,658,769 | 26.3 kb | Distal (>10kb) Multiome | 346 | |
| chr1:206,663,840–206,664,482 | 20.7 kb | Distal (>10kb) Multiome | 337 | |
| chr1:206,684,490–206,685,847 | 41 bp | At TSS Multiome | 492 | |
| chr1:206,685,899–206,686,288 | 995 bp | At TSS | 466 | |
| chr1:206,687,758–206,688,437 | 3.1 kb | Proximal (<10kb) Multiome | 218 | |
| chr1:206,909,139–206,910,281 | 224.6 kb | Distal (>10kb) Multiome | 445 |
Genomic view of the MAPKAPK2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.