Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Transcription factors with Perturb-seq knockdown data for MAPK4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAPK4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAPK4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:50,266,119–50,266,730 | 293.5 kb | Distal (>10kb) Multiome | 493 | |
| chr18:50,268,096–50,268,782 | 291.5 kb | Distal (>10kb) Multiome | 343 | |
| chr18:50,281,123–50,282,656 | 278.4 kb | Distal (>10kb) Multiome | 877 | |
| chr18:50,287,072–50,288,411 | 272.2 kb | Distal (>10kb) Multiome | 897 | |
| chr18:50,307,523–50,307,991 | 252.3 kb | Distal (>10kb) Multiome | 265 | |
| chr18:50,374,233–50,375,652 | 185.1 kb | Distal (>10kb) Multiome | 732 | |
| chr18:50,559,125–50,561,284 | 56 bp | At TSS Multiome | 350 | |
| chr18:50,784,562–50,785,070 | 224.8 kb | Distal (>10kb) Multiome | 166 | |
| chr18:50,819,413–50,820,437 | 259.9 kb | Distal (>10kb) Multiome | 590 |
Genomic view of the MAPK4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.