This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAP4K5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP4K5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP4K5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:50,311,389–50,313,095 | 248.8 kb | Distal (>10kb) Multiome HiCAR | 986 | |
| chr14:50,396,285–50,397,366 | 164.3 kb | Distal (>10kb) Multiome | 782 | |
| chr14:50,531,734–50,533,317 | 28.5 kb | Distal (>10kb) Multiome | 905 | |
| chr14:50,559,970–50,561,283 | 561 bp | At TSS Multiome | 524 | |
| chr14:50,667,319–50,668,903 | 107.2 kb | Distal (>10kb) Multiome | 914 | |
| chr14:50,823,525–50,824,353 | 262.8 kb | Distal (>10kb) Multiome | 183 | |
| chr14:50,829,783–50,831,951 | 270.1 kb | Distal (>10kb) Multiome | 634 |
Genomic view of the MAP4K5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.