The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAP3K11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP3K11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP3K11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:65,314,302–65,316,053 | 298.5 kb | Distal (>10kb) Multiome | 803 | |
| chr11:65,333,360–65,334,372 | 280.4 kb | Distal (>10kb) Multiome | 654 | |
| chr11:65,354,023–65,355,987 | 259.6 kb | Distal (>10kb) Multiome | 677 | |
| chr11:65,366,306–65,366,977 | 247.7 kb | Distal (>10kb) Multiome | 309 | |
| chr11:65,381,835–65,382,758 | 232.0 kb | Distal (>10kb) Multiome | 984 | |
| chr11:65,386,320–65,387,097 | 227.6 kb | Distal (>10kb) Multiome | 757 | |
| chr11:65,416,383–65,417,015 | 197.7 kb | Distal (>10kb) Multiome | 664 | |
| chr11:65,417,855–65,419,687 | 195.1 kb | Distal (>10kb) Multiome | 1018 | |
| chr11:65,421,858–65,423,533 | 191.8 kb | Distal (>10kb) Multiome | 1197 | |
| chr11:65,454,735–65,455,360 | 159.1 kb | Distal (>10kb) Multiome | 573 | |
| chr11:65,477,100–65,477,990 | 136.7 kb | Distal (>10kb) Multiome | 991 | |
| chr11:65,487,451–65,488,490 | 126.5 kb | Distal (>10kb) Multiome | 706 | |
| chr11:65,496,515–65,498,726 | 116.7 kb | Distal (>10kb) Multiome | 1059 | |
| chr11:65,506,702–65,508,865 | 107.0 kb | Distal (>10kb) Multiome | 864 | |
| chr11:65,524,475–65,525,724 | 89.2 kb | Distal (>10kb) Multiome | 711 | |
| chr11:65,538,923–65,541,339 | 73.4 kb | Distal (>10kb) Multiome | 733 | |
| chr11:65,546,285–65,547,091 | 67.5 kb | Distal (>10kb) Multiome | 529 | |
| chr11:65,553,318–65,554,003 | 60.6 kb | Distal (>10kb) Multiome | 195 | |
| chr11:65,569,718–65,570,745 | 44.0 kb | Distal (>10kb) Multiome | 930 | |
| chr11:65,571,973–65,573,008 | 41.8 kb | Distal (>10kb) Multiome | 420 | |
| chr11:65,573,788–65,575,269 | 39.9 kb | Distal (>10kb) Multiome | 742 | |
| chr11:65,575,601–65,576,322 | 38.2 kb | Distal (>10kb) Multiome | 527 | |
| chr11:65,591,808–65,592,698 | 22.0 kb | Distal (>10kb) Multiome | 169 | |
| chr11:65,606,536–65,607,917 | 7.1 kb | Proximal (<10kb) Multiome | 376 | |
| chr11:65,613,478–65,614,645 | 55 bp | At TSS Multiome | 702 | |
| chr11:65,614,954–65,616,793 | 1.3 kb | Proximal (<10kb) Multiome | 830 | |
| chr11:65,637,768–65,638,920 | 23.9 kb | Distal (>10kb) Multiome | 740 | |
| chr11:65,641,918–65,642,633 | 27.9 kb | Distal (>10kb) Multiome | 155 | |
| chr11:65,646,814–65,647,818 | 33.0 kb | Distal (>10kb) Multiome | 270 | |
| chr11:65,652,106–65,653,317 | 38.5 kb | Distal (>10kb) Multiome | 901 | |
| chr11:65,662,517–65,663,930 | 48.8 kb | Distal (>10kb) Multiome | 839 | |
| chr11:65,711,437–65,712,942 | 98.0 kb | Distal (>10kb) Multiome | 1143 | |
| chr11:65,720,215–65,720,955 | 106.4 kb | Distal (>10kb) Multiome | 821 | |
| chr11:65,779,808–65,781,988 | 165.8 kb | Distal (>10kb) Multiome | 764 | |
| chr11:65,785,898–65,789,101 | 174.2 kb | Distal (>10kb) Multiome | 478 | |
| chr11:65,817,968–65,818,502 | 204.0 kb | Distal (>10kb) Multiome | 694 | |
| chr11:65,833,325–65,834,189 | 219.6 kb | Distal (>10kb) Multiome | 396 | |
| chr11:65,856,804–65,858,748 | 242.8 kb | Distal (>10kb) Multiome | 972 | |
| chr11:65,859,034–65,861,240 | 246.4 kb | Distal (>10kb) Multiome | 1012 | |
| chr11:65,871,920–65,874,072 | 259.5 kb | Distal (>10kb) Multiome | 741 | |
| chr11:65,887,987–65,889,162 | 274.3 kb | Distal (>10kb) Multiome | 824 | |
| chr11:65,890,253–65,891,457 | 276.4 kb | Distal (>10kb) Multiome | 895 | |
| chr11:65,899,867–65,900,779 | 286.3 kb | Distal (>10kb) Multiome | 740 | |
| chr11:67,614,064–67,614,626 | 2000.0 kb | Distal (>10kb) Multiome HiCAR | 383 |
Genomic view of the MAP3K11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.