MAP2K6

mitogen-activated protein kinase kinase 6 | CRCMSL, MAPKK6, MEK6, MKK6, SAPKK3, PRKMK6

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]

Member of: DE-8 Developmental clusters: GC7

Biological processes 43 terms

ATP binding (GO:0005524)MAP kinase kinase activity (GO:0004708)MAP kinase kinase activity (GO:0004708)MAP kinase kinase activity (GO:0004708)MAP kinase kinase activity (GO:0004708)MAPK cascade (GO:0000165)MAPK cascade (GO:0000165)MAPK cascade (GO:0000165)bone development (GO:0060348)cellular senescence (GO:0090398)cellular senescence (GO:0090398)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoskeleton (GO:0005856)cytosol (GO:0005829)cytosol (GO:0005829)cytosol (GO:0005829)identical protein binding (GO:0042802)negative regulation of cold-induced thermogenesis (GO:0120163)negative regulation of cold-induced thermogenesis (GO:0120163)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)nucleus (GO:0005634)osteoblast differentiation (GO:0001649)p38MAPK cascade (GO:0038066)p38MAPK cascade (GO:0038066)p38MAPK cascade (GO:0038066)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein kinase binding (GO:0019901)protein kinase binding (GO:0019901)protein serine kinase activity (GO:0106310)protein serine/threonine kinase activity (GO:0004674)protein tyrosine kinase activity (GO:0004713)regulation of cell cycle (GO:0051726)regulation of intracellular signal transduction (GO:1902531)regulation of signal transduction by p53 class mediator (GO:1901796)signal transduction (GO:0007165)signal transduction in response to DNA damage (GO:0042770)stress-activated MAPK cascade (GO:0051403)stress-activated protein kinase signaling cascade (GO:0031098)stress-activated protein kinase signaling cascade (GO:0031098)

Expression (TPM)

TFs regulating MAP2K6 0 TFs

Transcription factors with Perturb-seq knockdown data for MAP2K6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP2K6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MAP2K6

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP2K6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:69,326,154–69,327,854	174.9 kb	Distal (>10kb) Multiome	969
chr17:69,412,260–69,413,562	89.5 kb	Distal (>10kb) Multiome	184
chr17:69,414,033–69,415,228	87.5 kb	Distal (>10kb) Multiome	574
chr17:69,417,733–69,418,320	3.0 kb	Proximal (<10kb)	115
chr17:69,448,378–69,449,196	53.4 kb	Distal (>10kb) Multiome	238
chr17:69,466,526–69,467,765	34.7 kb	Distal (>10kb) Multiome	254
chr17:69,501,630–69,501,778	374 bp	At TSS	121
chr17:69,501,903–69,502,490	at TSS	At TSS	293

Genome Browser

Genomic view of the MAP2K6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.