This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]
Transcription factors with Perturb-seq knockdown data for MAP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:208,406,386–208,407,453 | 1017.2 kb | Distal (>10kb) Multiome HiCAR | 324 | |
| chr2:209,208,033–209,210,222 | 214.7 kb | Distal (>10kb) Multiome | 321 | |
| chr2:209,298,652–209,299,936 | 124.4 kb | Distal (>10kb) Multiome | 105 | |
| chr2:209,305,077–209,308,685 | 116.3 kb | Distal (>10kb) Multiome | 373 | |
| chr2:209,423,435–209,424,894 | 98 bp | At TSS Multiome | 597 | |
| chr2:209,425,590–209,425,764 | 1.5 kb | Proximal (<10kb) | 123 | |
| chr2:209,426,514–209,426,701 | 2.5 kb | Proximal (<10kb) | 77 | |
| chr2:209,614,729–209,616,012 | 191.1 kb | Distal (>10kb) Multiome | 309 | |
| chr2:209,661,330–209,661,755 | at TSS | At TSS | 82 | |
| chr2:209,771,427–209,772,913 | 347.9 kb | Distal (>10kb) Multiome | 849 | |
| chr2:209,817,604–209,818,340 | 394.0 kb | Distal (>10kb) Multiome | 183 | |
| chr2:209,960,058–209,961,333 | 536.9 kb | Distal (>10kb) Multiome | 269 |
Genomic view of the MAP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.